Martin M S, Martin F, Michel M F, Hammann A
Research Group of Digestive Cancers, INSERM U.252, Faculty of Medicine, Dijon, France.
Virchows Arch A Pathol Anat Histopathol. 1991;418(3):193-9. doi: 10.1007/BF01606056.
Transplantable tumour lines were obtained from one duodenal carcinoma induced by N-methyl-N'-nitro-N-nitrosoguanidine in the Lewis rat and from six colonic carcinomas induced by 1,2 dimethylhydrazine in BDIX or Fisher rats. The tumours were serially transplanted by the subcutaneous route into homologous syngeneic rats. The seven tumours differ from one another in their histological structure, five of them being well or moderately differentiated adenocarcinomas, and in their capacity to produce neutral or acidic mucins. The seven tumours also differ in their growth rate. The seven lines produced metastases; the metastatic potential and the location of the metastases differed from one line to another. The seven lines kept their original differentiation characteristics through multiple passages, representing several years of transplantation into syngeneic hosts. These tumours represent a useful and diversified model of metastatic intestinal carcinoma, available for basic research and therapeutic trials.
可移植肿瘤系取自一只由N-甲基-N'-硝基-N-亚硝基胍诱导的Lewis大鼠十二指肠癌，以及六只由1,2-二甲基肼诱导的BDIX或Fisher大鼠结肠癌。这些肿瘤通过皮下途径连续移植到同基因的同源大鼠体内。这七种肿瘤在组织结构上彼此不同，其中五种为高分化或中分化腺癌，并且在产生中性或酸性粘蛋白的能力方面也存在差异。这七种肿瘤在生长速度上也有所不同。这七个品系都会发生转移；不同品系的转移潜能和转移部位各不相同。这七个品系在多次传代过程中保持了其原始的分化特征，相当于在同基因宿主中进行了数年的移植。这些肿瘤代表了一种有用且多样化的转移性肠道癌模型，可用于基础研究和治疗试验。
