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放射状胶质细胞。它们真的是神经胶质细胞吗?

Radial glial cells. are they really glia?

作者信息

Parnavelas J G, Nadarajah B

机构信息

Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom.

出版信息

Neuron. 2001 Sep 27;31(6):881-4. doi: 10.1016/s0896-6273(01)00437-8.

DOI:10.1016/s0896-6273(01)00437-8
PMID:11580889
Abstract

During the development of the cerebral cortex, radial glia serve as a scaffold to support and direct neurons during their migration. This view is now changing in the light of emerging evidence showing that these cells have a much more dynamic and diverse role. A recent series of studies has provided strong support for their role as precursor cells in the ventricular zone that generate cortical neurons and glia, in addition to providing migration guidance.

摘要

在大脑皮层发育过程中,放射状胶质细胞作为一种支架,在神经元迁移期间为其提供支持和引导。鉴于新出现的证据表明这些细胞具有更为动态和多样的作用,这一观点如今正在发生变化。最近的一系列研究有力地支持了它们作为脑室区前体细胞的作用,这些细胞除了提供迁移引导外,还能产生皮层神经元和神经胶质细胞。

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Radial glial cells. are they really glia?放射状胶质细胞。它们真的是神经胶质细胞吗?
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GFAP-expressing cells in the postnatal subventricular zone display a unique glial phenotype intermediate between radial glia and astrocytes.出生后脑室下区中表达胶质纤维酸性蛋白(GFAP)的细胞呈现出一种介于放射状胶质细胞和星形胶质细胞之间的独特胶质细胞表型。
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Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia.胚胎皮质脑室区的分裂前体细胞具有放射状胶质细胞的形态和分子特征。
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Multipotential and lineage restricted precursors coexist in the mammalian perinatal subventricular zone.多能和谱系受限的前体细胞共存于哺乳动物围产期脑室下区。
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Radial glia serve as neuronal progenitors in all regions of the central nervous system.放射状胶质细胞在中枢神经系统的所有区域都充当神经元祖细胞。
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