Parnavelas J G, Nadarajah B
Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom.
Neuron. 2001 Sep 27;31(6):881-4. doi: 10.1016/s0896-6273(01)00437-8.
During the development of the cerebral cortex, radial glia serve as a scaffold to support and direct neurons during their migration. This view is now changing in the light of emerging evidence showing that these cells have a much more dynamic and diverse role. A recent series of studies has provided strong support for their role as precursor cells in the ventricular zone that generate cortical neurons and glia, in addition to providing migration guidance.
在大脑皮层发育过程中,放射状胶质细胞作为一种支架,在神经元迁移期间为其提供支持和引导。鉴于新出现的证据表明这些细胞具有更为动态和多样的作用,这一观点如今正在发生变化。最近的一系列研究有力地支持了它们作为脑室区前体细胞的作用,这些细胞除了提供迁移引导外,还能产生皮层神经元和神经胶质细胞。