Macpherson A J, Hunziker L, McCoy K, Lamarre A
Institute of Experimental Immunology, Universitätsspital, Schmelzbergstrasse 12, CH8091, Zürich, Switzerland.
Microbes Infect. 2001 Oct;3(12):1021-35. doi: 10.1016/s1286-4579(01)01460-5.
IgA is the most abundant immunoglobulin produced in mammals; most is secreted as a dimer across mucous membranes. This review discusses the different mechanisms of induction of IgA, and its role in protecting mucosal surfaces against pathogenic and non-pathogenic microorganisms.
IgA是哺乳动物产生的最丰富的免疫球蛋白；大多数以二聚体形式分泌穿过粘膜。本文综述了诱导IgA产生的不同机制，以及它在保护粘膜表面免受致病性和非致病性微生物侵害方面的作用。
