Fagarasan Sidonia
Laboratory for Mucosal Immunity, RIKEN Research Center for Allergy and Immunology, 230-0045 Tsurumi, Yokohama, Japan.
Curr Opin Immunol. 2008 Apr;20(2):170-7. doi: 10.1016/j.coi.2008.04.002. Epub 2008 May 2.
Since its discovery as the most abundant Ig produced at mucosal surfaces, IgA has been the subject of continuous studies. The concepts emerged were that the precursors for IgA plasma cells are efficiently generated in follicular organized structures in the gut with the help of CD4 T cells and that secretory IgA provides protection against mucosal pathogens. Novel conceptual advances have been made in the past few years in describing new sites, mechanisms and functions of mucosal IgA synthesis.
自从被发现是黏膜表面产生的最丰富的免疫球蛋白以来，免疫球蛋白A一直是持续研究的对象。出现的概念是，免疫球蛋白A浆细胞的前体在肠道的滤泡组织结构中，在CD4 T细胞的帮助下高效生成，并且分泌型免疫球蛋白A提供针对黏膜病原体的保护。在过去几年里，在描述黏膜免疫球蛋白A合成的新部位、机制和功能方面取得了新的概念进展。
