正常男性精子中出现意外高比例的新生染色体t(11;22)易位。
Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males.
作者信息
Kurahashi H, Emanuel B S
机构信息
Division of Human Genetics and Molecular Biology, The Children's Hospital of Philadelphia, Abramson Research Center Building, 3516 Civic Center Boulevard, Philadelphia, Pennsylvania, USA.
出版信息
Nat Genet. 2001 Oct;29(2):139-40. doi: 10.1038/ng1001-139.
Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.
先前已对源自先天性t(11;22)(q23;q11)易位的连接片段进行了克隆和测序。在此我们报告，正常个体精子DNA中易位特异性PCR产物的发生率很高。这些正常个体以及其他正常个体或患有染色体断裂综合征的个体的体细胞DNA均未产生PCR连接片段，这表明这种易位发生在减数分裂期间。
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