顺二氯二氨铂（II）对艾氏腹水癌细胞肿瘤进展和程序性死亡的早期影响。
Early effects of cis-dichlorodiammine platinum (II) on tumor progression and programmed death of Ehrlich ascites carcinoma cells.
作者信息
Razin B V, Inzhevatkin E V, Nefedova V V, Egorova A B, Kazbanov V I, Nefedov V P
机构信息
International Research Center for Extreme Body States, Presidium of the Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences.
出版信息
Bull Exp Biol Med. 2001 Jun;131(6):568-9. doi: 10.1023/a:1012310820879.
We studied the effects of cis-dichlorodiammine platinum (II) on different pathways of cell death in cultured Ehrlich ascites carcinoma in vitro and on subsequent growth of transplanted tumor in vivo. One-hour incubation with the cytostatic modulated apoptosis in cell culture. However, exposure of cell culture to a minimal effective concentration of cis-platinum(II)diammine dichloride promoted the growth of transplanted tumor.
我们研究了顺二氯二氨合铂（II）对体外培养的艾氏腹水癌细胞不同细胞死亡途径以及对体内移植瘤后续生长的影响。在细胞培养中，与细胞生长抑制剂孵育1小时可调节细胞凋亡。然而，将细胞培养物暴露于最低有效浓度的顺铂（II）二氯二氨可促进移植瘤的生长。
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