Viala A, Cano J P, Durand A
J Chromatogr. 1975 Sep 3;111(2):299-303. doi: 10.1016/s0021-9673(00)99278-1.
A method is developed for the gas chromatographic determination of chloroquine after extraction from biological material, using medazepam as the internal standard and a column filled with 3% OV-17 on Gas-Chrom Q. The detection limits are: 0.15 mug/ml of urine, 0.25 mug/ml of whole blood, and 1.50 mug/g of tissue. The technique can be applied in toxicological analysis and in monitoring drug levels.
开发了一种从生物材料中提取后用气相色谱法测定氯喹的方法，使用地西泮作为内标，色谱柱填充有涂覆3%OV - 17的Gas - Chrom Q。检测限为：尿液0.15微克/毫升、全血0.25微克/毫升、组织1.50微克/克。该技术可应用于毒理学分析和药物水平监测。
