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血清素摄取减少或单胺氧化酶抑制未能阻止进食后大脑5-羟吲哚合成的加速。

Failure of decreased serotonin uptake or monoamine oxidase inhibition to block the acceleration in brain 5-hydroxyindole synthesis that follows food consumption.

作者信息

Jacoby J H, Colmenares J L, Wurtman R J

出版信息

J Neural Transm. 1975;37(1):25-32. doi: 10.1007/BF01249763.

DOI:10.1007/BF01249763
PMID:1159412
Abstract

The acceleration in brain serotonin synthesis produced by injecting rats with tryptophan or allowing them to consume a carbohydrate diet was not blocked by the prior elevation of brain serotonin levels (by administration of a MAO inhibitor: Lilly 51641) or by a treatment (chlorimipramine administration) that decreases impulse flow along serotoninergic neurons.

摘要

给大鼠注射色氨酸或让它们食用碳水化合物饮食所产生的脑血清素合成加速，不会被先前脑血清素水平的升高（通过给予单胺氧化酶抑制剂：礼来51641）或通过减少血清素能神经元冲动传导的治疗（给予氯米帕明）所阻断。

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Failure of decreased serotonin uptake or monoamine oxidase inhibition to block the acceleration in brain 5-hydroxyindole synthesis that follows food consumption.血清素摄取减少或单胺氧化酶抑制未能阻止进食后大脑5-羟吲哚合成的加速。
J Neural Transm. 1975;37(1):25-32. doi: 10.1007/BF01249763.
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The effect of isatin (tribulin) on metabolism of indoles in the rat brain and pineal: in vitro and in vivo studies.
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Long-term effects of 4-chloroamphetamine on brain 5-hydroxyindole metabolism in rats.4-氯苯丙胺对大鼠脑5-羟色胺代谢的长期影响。
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Effects of drugs on the processes regulating the functional activity of brain 5-hydroxytryptamine.
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Theanine-induced reduction of brain serotonin concentration in rats.
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Control of brain monoamine synthesis by diet and plasma amino acids.饮食和血浆氨基酸对脑单胺合成的调控
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Relationship between hypothalamic serotoninergic activity and prolactin and growth hormone secretion in the domestic cockerel.家公鸡下丘脑5-羟色胺能活性与催乳素和生长激素分泌之间的关系。
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Effects of monoamine oxidase inhibition by clorgyline, deprenil or tranylcypromine on 5-hydroxytryptamine concentrations in rat brain and hyperactivity following subsequent tryptophan administration.氯吉兰、丙炔苯丙胺或反苯环丙胺抑制单胺氧化酶对大鼠脑内5-羟色胺浓度及随后给予色氨酸后的多动的影响。
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引用本文的文献

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Brain net unidirectional uptake of alpha-[14c]methyl-L-tryptophan (alpha-MTrp) and its correlation with regional serotonin synthesis, tryptophan incorporation into proteins, and permeability surface area products of tryptophan and alpha-MTrp.脑网络对α-[14C]甲基-L-色氨酸（α-MTrp）的单向摄取及其与区域5-羟色胺合成、色氨酸掺入蛋白质以及色氨酸和α-MTrp的通透表面积乘积的相关性。
Neurochem Res. 2000 Dec;25(12):1537-46. doi: 10.1023/a:1026654116999.
2
Lack of effect of increased pineal serotonin content on H3-tryptophan uptake.
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本文引用的文献

1
Effect of dietary phenylalanine and tryptophan upon rat brain amine levels.膳食苯丙氨酸和色氨酸对大鼠脑胺水平的影响。
J Pharmacol Exp Ther. 1962 May;136:174-8.
2
End-product inhibition of tyrosine hydroxylase as a possible mechanism for regulation of norepinephrine synthesis.酪氨酸羟化酶的终产物抑制作为去甲肾上腺素合成调节的一种可能机制。
Mol Pharmacol. 1967 Nov;3(6):549-55.
3
Acceleration of norepinephrine synthesis in the rat submaxillary gland in vivo during sympathetic nerve stimulation.交感神经刺激期间大鼠颌下腺去甲肾上腺素合成在体内的加速。
Life Sci. 1967 Jan 1;6(1):45-51. doi: 10.1016/0024-3205(67)90360-8.
4
The determination of tryptophan in plasma, liver, and urine.血浆、肝脏及尿液中色氨酸的测定。
J Lab Clin Med. 1967 Jan;69(1):160-9.
5
Increased synthesis of norepinephrine and epinephrine in the intact rat during exercise and exposure to cold.在完整大鼠运动及暴露于寒冷环境期间，去甲肾上腺素和肾上腺素的合成增加。
J Pharmacol Exp Ther. 1966 Sep;153(3):440-7.
6
Further studies on tryptophan hydroxylase in rat brainstem and beef pineal.大鼠脑干和牛松果体中色氨酸羟化酶的进一步研究。
Biochem Pharmacol. 1969 May;18(5):1071-81. doi: 10.1016/0006-2952(69)90111-7.
7
Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-alpha-ethyl-meta-tyramine.抗抑郁药物对4-甲基-α-乙基-间酪氨酸所致脑内神经元5-羟色胺储备耗竭的影响。
Eur J Pharmacol. 1969 Mar;5(4):357-66. doi: 10.1016/0014-2999(69)90113-7.
8
Adrenal tyrosine hydroxylase: compensatory increase in activity after chemical sympathectomy.肾上腺酪氨酸羟化酶：化学性交感神经切除术后活性的代偿性增加。
Science. 1969 Jan 31;163(3866):468-9. doi: 10.1126/science.163.3866.468.
9
Kinetic studies and effects in vivo of a new monoamine oxidase inhibitor, N-[2-(o-chlorophenoxy)-ethyl]-cyclopropylamine.一种新型单胺氧化酶抑制剂N-[2-(邻氯苯氧基)-乙基]-环丙胺的动力学研究及体内效应
Biochem Pharmacol. 1968 Oct;17(10):2097-106. doi: 10.1016/0006-2952(68)90184-6.
10
The effect of nerve stimulation on the synthesis and metabolism of norepinephrine in the isolated guinea-pig hypogastric nerve-vas deferens preparation.神经刺激对离体豚鼠腹下神经 - 输精管标本中去甲肾上腺素合成与代谢的影响。
J Pharmacol Exp Ther. 1968 Mar;160(1):61-71.