Marinesco S, Poncet L, Debilly G, Jouvet M, Cespuglio R
Département de Médecine Expérimentale, Université Claude Bernard, Lyon, France.
Brain Res. 1996 Oct 14;736(1-2):82-90. doi: 10.1016/0006-8993(96)00681-6.
Tianeptine is a substance enhancing the serotonir uptake while sertraline and clomipramine inhibit it. By means of 5-hydroxyin-doleacetic acid (5-HIAA) voltammetric measurements, this study investigated their influence on serotonin metabolism which depends mainly upon the activity of monoamine oxidase type A. After tianeptine injection the 5-HIAA signal increased by about 60%. This effect was maintained when the animals were pre-treated with MDL 72145 (an inhibitor of monoamine oxidase type B) but reduced when clorgyline (an inhibitor of monoamine oxidase type A) was administered after tianeptine. Administration of sertraline or clomipramine reduced the 5-HIAA signal by about 30-50%, whether the animals were pre-treated with MDL 72145 or not. It is to be concluded that tianeptine, sertraline and clomipramine can regulate the 5-HT fraction present in the synaptic cleft, not only by acting at the level of the serotoninergic neurons, but also by favoring or reducing the access of the amine to monoamine oxidase type A which is synthesized within non-serotoninergic neurons and glial cells.
噻奈普汀是一种增强5-羟色胺摄取的物质，而舍曲林和氯米帕明则抑制其摄取。通过5-羟吲哚乙酸（5-HIAA）伏安法测量，本研究调查了它们对主要依赖于A型单胺氧化酶活性的5-羟色胺代谢的影响。注射噻奈普汀后，5-HIAA信号增加了约60%。当动物用MDL 72145（一种B型单胺氧化酶抑制剂）预处理时，这种效应得以维持，但在噻奈普汀后给予氯吉兰（一种A型单胺氧化酶抑制剂）时，效应减弱。无论动物是否用MDL 72145预处理，给予舍曲林或氯米帕明都会使5-HIAA信号降低约30%-50%。可以得出结论，噻奈普汀、舍曲林和氯米帕明不仅可以通过作用于5-羟色胺能神经元水平，还可以通过促进或减少胺进入在非5-羟色胺能神经元和神经胶质细胞内合成的A型单胺氧化酶，来调节突触间隙中存在的5-羟色胺部分。
