Kudoh A, Katagai H, Takazawa T, Matsuki A
Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Aomori, Japan.
Cytokine. 2001 Sep 7;15(5):270-3. doi: 10.1006/cyto.2001.0927.
We investigated the change of plasma cytokines concentrations in elderly patients during lower abdominal surgery. Plasma interleukin (IL-)6 concentrations (68.0+/-15.4 and 36.1+/-20.7 pg/ml) in elderly patients at 24 h and at 3 days after surgery were significantly higher than those (35.1+/-21.5 and 18.6+/-10.6 pg/ml) of young adults. Plasma IL-6 concentrations (92.3+/- 31.9 pg/ml) in elderly patients anesthetized with propofol and fentanyl were significantly higher at the end of the operation than that (57.9+/-36.7 pg/ml) of elderly patients anesthetized with sevoflurane and fentanyl. In conclusion, elderly patients have an increased and delayed IL-6 response to surgical trauma compared with young adults. Plasma IL-6 production after surgical trauma in elderly patients with total intravenous anesthesia with propofol was significantly higher than that in elderly patients with sevoflurane anesthesia.
我们研究了老年患者在下腹部手术期间血浆细胞因子浓度的变化。老年患者术后24小时和3天时的血浆白细胞介素（IL-）6浓度（68.0±15.4和36.1±20.7 pg/ml）显著高于年轻成年人（35.1±21.5和18.6±10.6 pg/ml）。丙泊酚和芬太尼麻醉的老年患者在手术结束时的血浆IL-6浓度（92.3±31.9 pg/ml）显著高于七氟醚和芬太尼麻醉的老年患者（57.9±36.7 pg/ml）。总之，与年轻成年人相比，老年患者对手术创伤的IL-6反应增强且延迟。丙泊酚全静脉麻醉的老年患者手术创伤后的血浆IL-6产生显著高于七氟醚麻醉的老年患者。
