Department of Anesthesiology, Botucatu Medical School, UNESP, Universidade Estadual Paulista, District of Rubiao Junior, Botucatu, São Paulo, Brazil, CEP: 18618-970.
Inflammation. 2012 Dec;35(6):1807-13. doi: 10.1007/s10753-012-9501-2.
Patients undergoing surgical procedure develop an inflammatory response due to surgical trauma that may be modulated by anesthetics. The aim of this study was to investigate the cytokine profile in the plasma of adult patients who underwent minimally invasive surgery with balanced anesthesia with propofol, fentanyl, and sevoflurane. The study included 15 healthy patients scheduled for tympanoplasty or septoplasty under balanced anesthesia. Blood samples were drawn at four time points: before anesthesia, before surgery, 120 min after anesthesia induction, and on the first postoperative day. Plasma interleukin (IL)-1β, -2, -4, -6, -8, -10, -12, TNF-α, and INF-γ levels were assessed by flow cytometry. IL-6 levels were elevated on the day after the surgery (p < 0.001). All other cytokines did not change either during or after balanced anesthesia (p > 0.05). In conclusion, balanced anesthesia with propofol, fentanyl, and sevoflurane anesthesia is not associated with intraoperative changes in the plasma cytokines in healthy patients undergoing minimally invasive otorhinological surgeries. Considering IL-6 results, a postoperative inflammatory response may have occurred due to surgical stress.
患者在接受手术创伤时会产生炎症反应，麻醉药物可能会对此产生调节作用。本研究旨在探究接受异丙酚、芬太尼和七氟醚平衡麻醉的微创外科手术成年患者的血浆细胞因子谱。该研究纳入了 15 名拟接受鼓室成形术或鼻中隔成形术的健康患者，均接受平衡麻醉。在四个时间点采集血样：麻醉前、手术前、麻醉诱导后 120 分钟和术后第一天。采用流式细胞术检测血浆白细胞介素（IL）-1β、-2、-4、-6、-8、-10、-12、TNF-α 和 INF-γ 水平。术后第一天 IL-6 水平升高（p<0.001）。在平衡麻醉期间或之后，所有其他细胞因子均未发生变化（p>0.05）。总之，在接受微创耳鼻喉科手术的健康患者中，异丙酚、芬太尼和七氟醚平衡麻醉与术中血浆细胞因子的变化无关。考虑到 IL-6 的结果，术后炎症反应可能是由于手术应激引起的。
