Kudoh A, Katagai H, Takazawa T
Department of Anesthesiology, University of Hirosdaki School of Medicine, Hirosaki National Hospital, 5 Zaifucho, Hirosaki 036, Aomori, Japan.
Cytokine. 2001 Jan 21;13(2):104-8. doi: 10.1006/cyto.2000.0802.
We investigated inflammatory cytokine response in chronic depressed patients during abdominal surgery. Twenty-five major depressed patients (Group D) and twenty-five patients (Group C) as the control were studied. Plasma interleukin 6 (IL-6), interleukin 8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) concentrations were measured before and at 15 min after induction of anesthesia, the end of surgery, 24 h and 3 days after the operation. Plasma IL-6 concentrations in Group D at the end of the operation and 24 h after surgery were significantly lower than those of Group C. The plasma IL-6 concentration (87.1+/-55.3 pg/ml) of patients scoring more than 18 points in the Hamilton depression-rating score at the end of the operation was significantly higher than 57.5+/-76.7 pg/ml of patients scoring less than 18 points. Plasma IL-8 concentration (6.1+/-3.2 pg/ml) in Group D at the end of the operation was significantly lower than 8.7+/-4.2 pg/ml of Group C. We conclude that plasma IL-6 and IL-8 response to surgical trauma is inhibited in chronic depressed patients. The IL-6 response to surgical trauma is depending on the clinical state of depression.
我们研究了慢性抑郁症患者腹部手术期间的炎症细胞因子反应。研究对象为25例重度抑郁症患者（D组）和25例作为对照的患者（C组）。在麻醉诱导前、诱导后15分钟、手术结束时、术后24小时和3天时测量血浆白细胞介素6（IL-6）、白细胞介素8（IL-8）和肿瘤坏死因子-α（TNF-α）浓度。D组患者在手术结束时和术后24小时的血浆IL-6浓度显著低于C组。手术结束时汉密尔顿抑郁评分超过18分的患者血浆IL-6浓度（87.1±55.3 pg/ml）显著高于评分低于18分的患者的57.5±76.7 pg/ml。D组患者在手术结束时的血浆IL-8浓度（6.1±3.2 pg/ml）显著低于C组的8.7±4.2 pg/ml。我们得出结论，慢性抑郁症患者对手术创伤的血浆IL-6和IL-8反应受到抑制。IL-6对手术创伤的反应取决于抑郁的临床状态。
