Jensen R
Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark.
Cephalalgia. 2001 Sep;21(7):786-9. doi: 10.1046/j.0333-1024.2001.00251.x.
Despite tension-type headache represents one of the most frequent and costly diseases in modern society only very little research on this disease has actually been carried out. In contrast to former belief tension-type headache is a separate entity that can and should be separated from migraine. No specific biochemical abnormalities have yet been identified but a reliable human model of tension-type headache has been developed by means of infusion of a NO-donor, glyceryl trinitrate. Myofascial factors and peripheral sensitization of nociceptors play an important role in the episodic form, and central sensitization has been demonstrated in the chronic form. As chronic tension-type headache usually evolves from the episodic form, prevention and reversal of this central sensitization may be an important target for future pathophysiological studies and drug development.
尽管紧张型头痛是现代社会中最常见且代价高昂的疾病之一，但实际上针对这种疾病的研究却非常少。与以往的认知不同，紧张型头痛是一种独立的病症，能够且应该与偏头痛区分开来。目前尚未发现特定的生化异常，但通过输注一氧化氮供体硝酸甘油，已建立了可靠的紧张型头痛人体模型。肌筋膜因素和伤害感受器的外周敏化在发作性形式中起重要作用，而在慢性形式中已证实存在中枢敏化。由于慢性紧张型头痛通常由发作性形式演变而来，预防和逆转这种中枢敏化可能是未来病理生理学研究和药物开发的重要目标。
