Carson J H, Cui H, Barbarese E
Department of Biochemistry, University of Connecticut Health Center, Farmington, CT 06030, USA.
Curr Opin Neurobiol. 2001 Oct;11(5):558-63. doi: 10.1016/s0959-4388(00)00249-x.
In the past two years, several different RNA trafficking pathways have been characterized in oligodendrocytes; similar trafficking pathways have been discovered in neuronal and retroviral systems; co-assembly of multiple different RNAs into the same granules has been analyzed as a mechanism for coordinating gene expression; and a new hypothesis for RNA trafficking, based on the balance of power between kinesin and dynein in individual RNA granules, has been proposed.
在过去两年中，少突胶质细胞中的几种不同RNA转运途径已得到表征；在神经元和逆转录病毒系统中也发现了类似的转运途径；已分析了多种不同RNA共同组装到同一颗粒中作为协调基因表达的一种机制；并且基于单个RNA颗粒中驱动蛋白和动力蛋白之间的力量平衡，提出了一种RNA转运的新假说。
