动物细胞中的亚细胞mRNA定位及其重要性。
Subcellular mRNA localization in animal cells and why it matters.
作者信息
Holt Christine E, Bullock Simon L
机构信息
Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.
出版信息
Science. 2009 Nov 27;326(5957):1212-6. doi: 10.1126/science.1176488.
Abstract
Subcellular localization of messenger RNAs (mRNAs) can give precise control over where protein products are synthesized and operate. However, just 10 years ago many in the broader cell biology community would have considered this a specialized mechanism restricted to a very small fraction of transcripts. Since then, it has become clear that subcellular targeting of mRNAs is prevalent, and there is mounting evidence for central roles for this process in many cellular events. Here, we review current knowledge of the mechanisms and functions of mRNA localization in animal cells.
摘要
信使核糖核酸（mRNA）的亚细胞定位能够精确控制蛋白质产物的合成位置及发挥作用的位置。然而，就在仅仅10年前，更广泛的细胞生物学界的许多人还会认为这是一种仅限于极少数转录本的特殊机制。从那时起，很明显mRNA的亚细胞靶向是普遍存在的，并且越来越多的证据表明这一过程在许多细胞事件中发挥着核心作用。在这里，我们综述了动物细胞中mRNA定位的机制和功能的当前知识。
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