Villa Tommaso, Rougemaille Mathieu, Libri Domenico
LEA Laboratory of Nuclear RNA Metabolism, Centre de Génétique Moléculaire, CNRS-UPR2167, Gif sur Yvette, France.
Biochim Biophys Acta. 2008 Sep;1779(9):524-31. doi: 10.1016/j.bbagrm.2008.06.009. Epub 2008 Jul 1.
From the very first time they set foot in the nuclear landscape till the end of their life, RNAs are packaged in ribonucleoproteins (RNPs) and face numerous processing steps to achieve function. To avoid the catastrophic consequences of naturally occurring processing errors, cells employ numerous quality control strategies. Focusing on yeast as a model system, we will review here how nuclear mechanisms ensure the proper assembly and maturation of mRNPs for their release in the cytoplasm, and highlight how these mechanisms are exploited to shape the RNA polymerase II transcriptome.
从首次踏入核环境直至生命结束，RNA都被包装在核糖核蛋白（RNP）中，并经历众多加工步骤以实现其功能。为避免自然发生的加工错误带来灾难性后果，细胞采用了多种质量控制策略。本文将以酵母作为模型系统，回顾核机制如何确保mRNA-核糖核蛋白颗粒（mRNP）正确组装和成熟以便释放到细胞质中，并着重介绍这些机制如何被用于塑造RNA聚合酶II转录组。
