蓖麻毒素

Ricin.

作者信息

Olsnes S, Kozlov J V

机构信息

Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310, Oslo, Norway.

出版信息

Toxicon. 2001 Nov;39(11):1723-8. doi: 10.1016/s0041-0101(01)00158-1.

DOI:10.1016/s0041-0101(01)00158-1

PMID:11595634

Abstract

The plant toxin ricin consists of two disulfide-linked polypeptides with different functions. The A-chain enters the cytosol and inactivates the ribosomes enzymatically, whereas the B-chain has lectin properties and binds to carbohydrates at the cell surface. This binding is a requirement for translocation of the A-chain to the cytosol. The bound toxin is endocytosed and transported retrograde through the Golgi apparatus to the endoplasmic reticulum where it appears to be translocated to the cytosol by the sec61p complex.

摘要

植物毒素蓖麻毒素由两个具有不同功能的通过二硫键相连的多肽组成。A链进入细胞质溶胶并通过酶促作用使核糖体失活，而B链具有凝集素特性，可与细胞表面的碳水化合物结合。这种结合是A链转运至细胞质溶胶的必要条件。结合后的毒素被内吞，并通过高尔基体逆行运输至内质网，在那里它似乎通过sec61p复合体转运至细胞质溶胶。