Rodrigues Éllen F, Verza Flavia Alves, Nishimura Felipe Garcia, Beleboni Renê Oliveira, Hermans Cedric, Janssens Kaat, De Mol Maarten Lieven, Hulpiau Paco, Marins Mozart
Postgraduate Program in Environmental Technology, University of Ribeirão Preto/UNAERP, Ribeirão Preto 14096-900, SP, Brazil.
Biotechnology Unit, University of Ribeirão Preto/UNAERP, Ribeirão Preto 14096-900, SP, Brazil.
Mar Drugs. 2024 Dec 26;23(1):8. doi: 10.3390/md23010008.
Lectins are non-covalent glycan-binding proteins found in all living organisms, binding specifically to carbohydrates through glycan-binding domains. Lectins have various biological functions, including cell signaling, molecular recognition, and innate immune responses, which play multiple roles in the physiological and developmental processes of organisms. Moreover, their diversity enables biotechnological exploration as biomarkers, biosensors, drug-delivery platforms, and lead molecules for anticancer, antidiabetic, and antimicrobial drugs. Lectins from Rhodophytes (red seaweed) have been extensively reported and characterized for their unique molecular structures, carbohydrate-binding specificities, and important biological activities. The increasing number of sequenced Rhodophyte genomes offers the opportunity to further study this rich source of lectins, potentially uncovering new ones with properties significantly different from their terrestrial plant counterparts, thus opening new biotechnological applications. We compiled literature data and conducted an in-depth analysis of the phycolectomes from all Rhodophyta genomes available in NCBI datasets. Using Hidden Markov Models capable of identifying lectin-type domains, we found at least six different types of lectin domains present in Rhodophytes, demonstrating their potential in identifying new lectins. This review integrates a computational analysis of the Rhodophyte phycolectome with existing information on red algae lectins and their biotechnological potential.
凝集素是存在于所有生物中的非共价聚糖结合蛋白，通过聚糖结合结构域特异性结合碳水化合物。凝集素具有多种生物学功能，包括细胞信号传导、分子识别和先天免疫反应，在生物体的生理和发育过程中发挥多种作用。此外，它们的多样性使其能够作为生物标志物、生物传感器、药物递送平台以及抗癌、抗糖尿病和抗菌药物的先导分子进行生物技术探索。来自红藻门（红藻）的凝集素因其独特的分子结构、碳水化合物结合特异性和重要的生物活性而被广泛报道和表征。红藻门基因组测序数量的增加为进一步研究这种丰富的凝集素来源提供了机会，有可能发现具有与陆生植物同类凝集素显著不同特性的新凝集素，从而开辟新的生物技术应用领域。我们收集了文献数据，并对NCBI数据集中所有红藻门基因组的藻凝集素组进行了深入分析。使用能够识别凝集素类型结构域的隐马尔可夫模型，我们发现红藻中至少存在六种不同类型的凝集素结构域，证明了它们在鉴定新凝集素方面的潜力。本综述将红藻藻凝集素组的计算分析与关于红藻凝集素及其生物技术潜力的现有信息相结合。
