Steer H W, Colin-Jones D G
J Pathol. 1975 Apr;115(4):199-205. doi: 10.1002/path.1711150403.
Colonic biopsies from six patients with normal colons and seven patients with melanosis coli were studied ultrastructurally and histochemically for lysosomal enzymes. Anthraquinone purgatives were found to increase the number of macrophages in the connective tissue of the colonic mucosa. In addition, they cause an increase in the intensity of lysosomal activity and an increase in the number of lysosomes in macrophages, Schwann cells and neurones of the submucosal plexus of the colonic mucosa.
对6名结肠正常患者和7名患结肠黑变病患者的结肠活检组织进行了溶酶体酶的超微结构和组织化学研究。发现蒽醌类泻药会增加结肠黏膜结缔组织中巨噬细胞的数量。此外，它们还会导致溶酶体活性增强，以及结肠黏膜黏膜下丛的巨噬细胞、施万细胞和神经元中溶酶体数量增加。
