Xia Y, Li Z, Zhu D, Yan Y
Department of Chinese Medicinal Prescription, China Pharmaceutical University, Nanjing 210038.
Zhongguo Zhong Yao Za Zhi. 1998 Apr;23(4):230-1, 255.
To clarify the material base of the distinct curative effect of Shengmaisan (SMS) compound prescription, a study was made on the dynamics of chemical constituents in the decoction prepared according to the compound prescription. From the decoction a new compound was isolated and identified by UV, IR, MS and NMR as 5-hydroxymethy-2-furaldehyde (5-HMF). The study suggests that the distinct curative effect of SMS compound prescription hinges on a material base which is different chemically from that in the other three single drugs used separately, thus presenting scientific criteria for rational compatibility and quality check in making preparations on compound prescriptions.
为阐明升脉散（SMS）复方独特疗效的物质基础，对按复方制备的汤剂中化学成分的动态变化进行了研究。从该汤剂中分离出一种新化合物，并通过紫外光谱（UV）、红外光谱（IR）、质谱（MS）和核磁共振（NMR）鉴定为5-羟甲基-2-糠醛（5-HMF）。该研究表明，SMS复方独特的疗效取决于一种物质基础，其化学组成与单独使用的其他三种单味药不同，从而为复方制剂的合理配伍和质量控制提供了科学依据。
