Zhu D, Li Z, Yan Y, Zhu J
Department of Chinese Medicinal Prescription, China Pharmaceutical University, Nanjing 210038.
Zhongguo Zhong Yao Za Zhi. 1998 May;23(5):291-3, 319-20.
The content changes of 5-hydroxymethyl-2-furaldehyde(5-HMF), a new compound reported in the previous paper, in eight prescriptions of different composition were further determined by HPLC with a view to find the chemical dynamic changes and compatibility of medicines. The contents of 5-HMF in different combinations of Radix Ophiopogonis and Fructus Schisandrae, different boiling times and boiling frequency were examined. The results indicated that 5-HMF was produced in the boiling process of Radix Ophiopogonis and Fructus Schisandra combined. The contents of 5-HMF would increase with the increase of Radix Ophiopogonis amount, reaching the highest value after 1.5 h boiling and two times of boiling.
通过高效液相色谱法进一步测定了前期报道的新化合物5-羟甲基-2-糠醛（5-HMF）在8种不同组方中的含量变化，旨在探寻其化学动态变化及药物配伍关系。考察了麦冬与五味子不同配伍组合、不同煎煮时间及煎煮次数下5-HMF的含量。结果表明，麦冬与五味子合煎过程中会产生5-HMF。5-HMF的含量会随着麦冬用量的增加而升高，煎煮1.5小时及煎煮两次后达到最高值。
