发酵支原体培养上清液中的一种4.1千道尔顿的多肽是诱导人牙龈成纤维细胞产生白细胞介素-6的物质之一。
A 4.1-kilodalton polypeptide in the cultural supernatant of Mycoplasma fermentans is one of the substances responsible for induction of interleukin-6 production by human gingival fibroblasts.
作者信息
Hasebe A, Shibata K, Watanabe T
机构信息
Department of Oral Pathobiological Science, Graduate School of Dental Medicine, Hokkaido University, Nishi 7, Kita 13, Kita-ku, Sapporo 060-8586, Japan.
出版信息
Infect Immun. 2001 Nov;69(11):7173-7. doi: 10.1128/IAI.69.11.7173-7177.2001.
Abstract
The cultural supernatant of Mycoplasma fermentans induced interleukin-6 production by human gingival fibroblasts. The active entities were divided into hydrophilic and hydrophobic substances. In this study, we purified a 4.1-kilodalton polypeptide from the hydrophilic substances. It reacted with polyclonal antibodies to M. fermentans and activated human macrophages.
摘要
发酵支原体的培养上清液可诱导人牙龈成纤维细胞产生白细胞介素-6。活性物质分为亲水物质和疏水物质。在本研究中，我们从亲水物质中纯化出一种4.1千道尔顿的多肽。它可与抗发酵支原体的多克隆抗体发生反应，并激活人巨噬细胞。
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