Shen Y, Zeng N, Jia M, Zhang Y, Wei Y, Ma Y
Chengdu University of TCM, Chengdu 610075.
Zhongguo Zhong Yao Za Zhi. 1998 Nov;23(11):687-90, 704-inside back cover.
To observe and compare the anti-inflammatory, antipyretic and diuretic effects of three kinds of Tongcao(Tongtuomu, Panyezhangyeshu and Luosan) and seven kinds of Xiao-tongcao(Ximashanjinjiehua, Xinanxiuqiu1. 2., Ditanghua, Suixuezhangcai, Qingjiaye and Zhongguo jinjiehua).
Decoctions prepared from the above kinds of Tongcao and Xiao-tongcao crude drugs were given to rats at dosages of 8 g/kg and 4 g/kg by ig. Pharmacological actions were observed by means of carrageenan-induced swelling paws, fever models induced by beer-yeast or carrageenan and metabolic cage method in rats.
All the experimental decoctions could inhibit carrageenan-induced swelling of rat paws in different degrees and exerted anti-pyretic effect on rat fever models induced by beer-yeast or carrageenan. Three kinds of Xiaotongcao(Ximashanjingjiehua, Xinanxiuqui2., Zhongguojinjiehua) had obvious diuretic effect on rats.
Decoctions of different species of Tongcao and Xiao-tongcao all have anti-inflammatory, antipyretic and diuretic effects, thus providing some pharmacologic basis for the efficacy assay, clinical application, species collation and quality study of Tongcao and Xiao-tongcao.
观察并比较三种通草（通脱木、盘叶掌叶树、罗伞）及七种小通草（喜马拉雅旌节花、西南绣球1.2.、地棠花、穗序掌柴、青荚叶、中国旌节花）的抗炎、解热及利尿作用。
将上述通草及小通草的生药制成水煎液，按8 g/kg和4 g/kg的剂量给大鼠灌胃。采用角叉菜胶致大鼠足肿胀、啤酒酵母或角叉菜胶致大鼠发热模型及代谢笼法观察其药理作用。
所有受试水煎液均能不同程度抑制角叉菜胶所致大鼠足肿胀，对啤酒酵母或角叉菜胶所致大鼠发热模型均有解热作用。三种小通草（喜马拉雅旌节花、西南绣球2.、中国旌节花）对大鼠有明显利尿作用。
不同种通草及小通草水煎液均有抗炎、解热及利尿作用，为通草及小通草的药效学评价、临床应用、品种整理及质量研究提供了一定的药理依据。
