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[海风藤对β-淀粉样前体蛋白基因表达的抑制作用]

[Inhibition of beta-amyloid precursor protein gene expression by haifengteng].

作者信息

Han E, Rajiv J

机构信息

Department of Neurology, Affiliated Hospital of Shandong Medical University, Jinan 250012.

出版信息

Zhongguo Zhong Yao Za Zhi. 1998 Nov;23(11):691-3, inside back cover.

PMID:11599352
Abstract

OBJECTIVE

To study the inhibition of beta-amyloid precursor protein(beta-APP) gene expression by Haifengteng.

METHOD

Northern Blot analysis was used to investigate the level of beta-APP mRNA, and cell viability, LDH-release and colony formation assay were used to study the effect of Hairengteng of neurons.

RESULT

Haifengteng inhibited the expression of beta-APP gene selectively without causing cell injuries.

CONCLUSION

beta-APP is closely related to Alzheimer's disease. The findings in this study could be a basis for Haifengteng to have therapeutic potentials in treating Alzheimer's disease.

摘要

目的

研究海风藤对β-淀粉样前体蛋白（β-APP）基因表达的抑制作用。

方法

采用Northern印迹分析检测β-APP mRNA水平，通过细胞活力、乳酸脱氢酶释放及集落形成试验研究海风藤对神经元的影响。

结果

海风藤选择性抑制β-APP基因表达，且不引起细胞损伤。

结论

β-APP与阿尔茨海默病密切相关。本研究结果可为海风藤治疗阿尔茨海默病的潜在治疗作用提供依据。

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