Datsenko Z M, Krivenko O M, Nechitaĭlo L O
Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
Ukr Biokhim Zh (1999). 2001 Jan-Feb;73(1):60-4.
As a result of experiments conducted the marine phospholipids preparation enriched by omega-3 fatty acids was defined to modify fatty acids content due to changes of fatty acids level change in the neutral lipids and phospholipids fractions. As well it was identified, that at the oxidative stress induced by administration of CCl4 the growth of arachidonic and docozahexaenoic acids in the neutral lipids fractions was observed if compare with the norm. At the same time, the presented fatty acids in the phospholipids fractions remained unchanged. At oxidative stress the phospholipids fraction reacts to levels of arachidonic and docozahexaenoic acids just only as a result of administrating phospholipids with omega-3 fatty acids. The most attractive is the change of correlation C20:4/C22:6--increasing at administration of CCl4 and decreasing both at phospolipids and vitamin E injection. Thus, at the oxidative stress the first reacting ones are the fatty acids of neutral lipids microsomal membranes.
通过实验发现，富含ω-3脂肪酸的海洋磷脂制剂可因中性脂质和磷脂组分中脂肪酸水平的变化而改变脂肪酸含量。此外还发现，在给予CCl4诱导的氧化应激下，与正常情况相比，中性脂质组分中花生四烯酸和二十二碳六烯酸的含量有所增加。与此同时，磷脂组分中的上述脂肪酸含量保持不变。在氧化应激状态下，磷脂组分对花生四烯酸和二十二碳六烯酸水平的反应仅仅是由于给予了含ω-3脂肪酸的磷脂。最引人注目的是C20:4/C22:6相关性的变化——在给予CCl4时增加，而在注射磷脂和维生素E时均降低。因此，在氧化应激状态下，首先发生反应的是中性脂质微粒体膜中的脂肪酸。
