维生素A缺乏大鼠肝脏微粒体膜流动性和脂质特征
Liver microsomal membrane fluidity and lipid characteristics in vitamin A-deficient rats.
作者信息
Hamm M W, Chan V, Wolf G
机构信息
Department of Nutrition, Rutgers University, New Brunswick, NJ 08903.
出版信息
Biochem J. 1987 Aug 1;245(3):907-10. doi: 10.1042/bj2450907.
Abstract
Rat liver microsomes (microsomal fraction) were isolated from vitamin A-deficient and -sufficient rats and analysed for membrane lipid characteristics. Membrane fluidity was found to be significantly decreased in microsomes from the vitamin A-deficient rats, but not in liposomes prepared from lipid extracts. Microsomes from vitamin A-deficient animals showed a significant decrease in C18:2, omega 6 and an increase in C22:5, omega 6 fatty acids.
摘要
从维生素A缺乏和充足的大鼠中分离出大鼠肝脏微粒体（微粒体部分），并分析其膜脂特性。发现维生素A缺乏大鼠的微粒体膜流动性显著降低，但从脂质提取物制备的脂质体中未出现这种情况。维生素A缺乏动物的微粒体中C18:2、ω6显著减少，C22:5、ω6脂肪酸增加。
相似文献
1
Liver microsomal membrane fluidity and lipid characteristics in vitamin A-deficient rats.维生素A缺乏大鼠肝脏微粒体膜流动性和脂质特征
Biochem J. 1987 Aug 1;245(3):907-10. doi: 10.1042/bj2450907.
2
Vitamin E, membrane order, and antioxidant behavior in lung microsomes and reconstituted lipid vesicles.肺微粒体和重组脂质囊泡中的维生素E、膜有序性及抗氧化行为
Toxicol Appl Pharmacol. 1988 Oct;96(1):101-14. doi: 10.1016/0041-008x(88)90252-9.
3
Glucocorticoids increase the fluidity of the fetal-rat liver microsomal membrane in the perinatal period.糖皮质激素在围产期可增加胎鼠肝微粒体膜的流动性。
Biochem J. 1986 Oct 1;239(1):41-5. doi: 10.1042/bj2390041.
4
5
Fetal and adult human liver differ markedly in the fluidity and lipid composition of their microsomal membranes.
Hepatology. 1987 Jan-Feb;7(1):55-60. doi: 10.1002/hep.1840070113.
6
Microsomal lipid peroxidation causes an increase in the order of the membrane lipid domain.微粒体脂质过氧化导致膜脂区域有序性增加。
FEBS Lett. 1982 Jun 1;142(1):59-62. doi: 10.1016/0014-5793(82)80219-6.
7
The effect of dietary essential fatty acid deficiency on the composition and properties of the liver microsomal membrane of rats.膳食必需脂肪酸缺乏对大鼠肝脏微粒体膜组成和性质的影响。
J Nutr. 1988 Nov;118(11):1311-8. doi: 10.1093/jn/118.11.1311.
8
Chronic administration of ursodeoxycholic and tauroursodeoxycholic acid changes microsomal membrane lipid content and fatty acid compositions in rats.长期给予熊去氧胆酸和牛磺熊去氧胆酸会改变大鼠微粒体膜脂质含量和脂肪酸组成。
Biochem Biophys Res Commun. 1996 Mar 27;220(3):479-83. doi: 10.1006/bbrc.1996.0430.
9
Liver ischemia increases the molecular order of microsomal membranes by increasing the cholesterol-to-phospholipid ratio.肝脏缺血通过提高胆固醇与磷脂的比例来增加微粒体膜的分子有序性。
J Biol Chem. 1984 Nov 10;259(21):13217-23.
10
Dietary oxidized linoleic acid modifies lipid composition of rat liver microsomes and increases their fluidity.膳食氧化亚油酸会改变大鼠肝脏微粒体的脂质组成并增加其流动性。
J Nutr. 1997 May;127(5):681-6. doi: 10.1093/jn/127.5.681.
引用本文的文献
1
Comparative effects of beta-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats.β-胡萝卜素和岩藻黄质对大鼠视黄醇缺乏诱导的氧化应激的比较作用。
Mol Cell Biochem. 2009 Nov;331(1-2):59-67. doi: 10.1007/s11010-009-0145-y. Epub 2009 May 7.
2
Fucoxanthin restrains oxidative stress induced by retinol deficiency through modulation of Na(+)K(+)-ATPase [corrected] and antioxidant enzyme activities in rats.岩藻黄质通过调节大鼠体内钠钾-ATP酶[校正后]和抗氧化酶活性来抑制视黄醇缺乏诱导的氧化应激。
Eur J Nutr. 2008 Dec;47(8):432-41. doi: 10.1007/s00394-008-0745-4. Epub 2008 Oct 13.
3
Influence of retinol deficiency and curcumin/turmeric feeding on tissue microsomal membrane lipid peroxidation and fatty acids in rats.视黄醇缺乏及姜黄素/姜黄喂养对大鼠组织微粒体膜脂质过氧化和脂肪酸的影响。
Mol Cell Biochem. 1997 Oct;175(1-2):43-8. doi: 10.1023/a:1006829010327.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
3
Phosphorus assay in column chromatography.柱色谱法中的磷测定
J Biol Chem. 1959 Mar;234(3):466-8.
4
Study of the ferric chloride method for determination of total cholesterol and cholesterol esters.用于测定总胆固醇和胆固醇酯的氯化铁法研究。
Am J Clin Pathol. 1959 Apr;31(4):305-9. doi: 10.1093/ajcp/31.4.305.
5
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
6
Studies on the function of vitamin A in metabolism.维生素A在新陈代谢中的功能研究。
J Biol Chem. 1957 Apr;225(2):995-1008.
7
Dietary induction of acyl chain desaturases alters the lipid composition and fluidity of rat hepatocyte plasma membranes.通过饮食诱导酰基链去饱和酶可改变大鼠肝细胞质膜的脂质组成和流动性。
Biochemistry. 1984 Mar 13;23(6):1165-70. doi: 10.1021/bi00301a021.
8
Enhancement in 'apparent' membrane microviscosity during differentiation of embryonal carcinoma cells induced by retinoids.
Exp Cell Res. 1982 Apr;138(2):494-8. doi: 10.1016/0014-4827(82)90207-5.
9
Effect of vitamin A deficiency on mitochondrial lipids in rat liver.
J Nutr. 1969 Jan;97(1):8-12. doi: 10.1093/jn/97.1.8.
10
Phospholipid metabolism in vitamin A-deficientrats.维生素A缺乏大鼠的磷脂代谢
J Nutr. 1971 Feb;101(2):161-8. doi: 10.1093/jn/101.2.161.
Zotero 插件