维生素A缺乏大鼠肝脏微粒体膜流动性和脂质特征
Liver microsomal membrane fluidity and lipid characteristics in vitamin A-deficient rats.
作者信息
Hamm M W, Chan V, Wolf G
机构信息
Department of Nutrition, Rutgers University, New Brunswick, NJ 08903.
出版信息
Biochem J. 1987 Aug 1;245(3):907-10. doi: 10.1042/bj2450907.
Abstract
Rat liver microsomes (microsomal fraction) were isolated from vitamin A-deficient and -sufficient rats and analysed for membrane lipid characteristics. Membrane fluidity was found to be significantly decreased in microsomes from the vitamin A-deficient rats, but not in liposomes prepared from lipid extracts. Microsomes from vitamin A-deficient animals showed a significant decrease in C18:2, omega 6 and an increase in C22:5, omega 6 fatty acids.
摘要
从维生素A缺乏和充足的大鼠中分离出大鼠肝脏微粒体（微粒体部分），并分析其膜脂特性。发现维生素A缺乏大鼠的微粒体膜流动性显著降低，但从脂质提取物制备的脂质体中未出现这种情况。维生素A缺乏动物的微粒体中C18:2、ω6显著减少，C22:5、ω6脂肪酸增加。
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