Lepore D A, Knight K R, Anderson R L, Morrison W A
Immunology Research Center, St Vincent's Hospital, Fitzroy, Melbourne, Victoria, Australia.
Cell Stress Chaperones. 2001 Apr;6(2):93-6. doi: 10.1379/1466-1268(2001)006<0093:ropsah>2.0.co;2.
Ischemia-reperfusion injury limits the survival of muscle involved in tissue trauma or transfers during microsurgical reconstruction. Priming stresses such as ischemic preconditioning or mild hyperthermia have frequently been associated with improved survival of ischemic-reperfused cardiac muscle, such protection coinciding with induction of the stress-related heat shock protein 70 (Hsp70). Little is known about the response of skeletal muscle to priming stresses. This review summarizes the current knowledge on the use of priming stresses as protective strategies against the consequences of ischemia-reperfusion in cardiac and skeletal muscle and the potential role of Hsp70.
缺血再灌注损伤限制了显微外科重建过程中涉及组织创伤或转移的肌肉的存活。诸如缺血预处理或轻度热疗等预处理应激常常与缺血再灌注心肌存活率的提高相关，这种保护作用与应激相关热休克蛋白70（Hsp70）的诱导相吻合。关于骨骼肌对预处理应激的反应知之甚少。本综述总结了目前关于使用预处理应激作为针对心脏和骨骼肌缺血再灌注后果的保护策略的知识以及Hsp70的潜在作用。
