Röhl A, Brinkmann B, Forster L, Forster P
Institut für Rechtsmedizin, University of Münster, Germany.
Int J Legal Med. 2001 Aug;115(1):29-39. doi: 10.1007/s004140100217.
We have compiled a database of mitochondrial DNA (mtDNA) control region, hypervariable regions 1 (HVR1) and 2 (HVR2) sequences of a total of 14,138 individuals compiled from 103 mtDNA publications before 1 January 2000, 13 data sets published in 2000 and 2001 and 2 unpublished data sets of Iraqi Kurds and Indians from Kerala. By contacting the authors and by other means, we have confirmed and corrected sequence errors, eliminated duplications and harmonised the sequence format. These changes affected all but 26 of the 116 publications. Furthermore, we have implemented a geographic information system ("mtradius") which searches for closest matches to a given mtDNA control region sequence and displays them on a geographic map. A potential application is to estimate a chance matching probability when a forensic stain and a suspect have an identical mtDNA sequence: we suggest that the geographic area with the highest frequency of closely related mtDNA sequence types may be used to define a reference population to give the suspect the maximum benefit of doubt in accordance with the ceiling principle.
我们汇编了一个线粒体DNA（mtDNA）控制区、高变区1（HVR1）和高变区2（HVR2）序列的数据库，该数据库包含从2000年1月1日前的103篇mtDNA出版物、2000年和2001年发表的13个数据集以及伊拉克库尔德人和喀拉拉邦印度人的2个未发表数据集中选取的总共14138个个体的序列。通过与作者联系及其他方式，我们确认并纠正了序列错误，消除了重复序列，并统一了序列格式。这些更改影响了116篇出版物中的1 . . 26篇。此外，我们还实施了一个地理信息系统（“mtradius”），该系统可搜索与给定mtDNA控制区序列最接近的匹配项，并将其显示在地理地图上。一个潜在的应用是，当法医样本和嫌疑人的mtDNA序列相同时，估计匹配概率：我们建议，与mtDNA序列类型密切相关的频率最高的地理区域可用于定义一个参考人群，以便根据上限原则给予嫌疑人最大程度的疑罪从无待遇。
