一个来自162名日本人的线粒体DNA高变区I和II序列的新数据库。
A new database of mitochondrial DNA hypervariable regions I and II sequences from 162 Japanese individuals.
作者信息
Imaizumi K, Parsons T J, Yoshino M, Holland M M
机构信息
National Research Institute of Police Science, Kashiwa, Chiba, Japan.
出版信息
Int J Legal Med. 2002 Apr;116(2):68-73. doi: 10.1007/s004140100211.
A database of mitochondrial DNA (mtDNA) hypervariable region 1 (HV1) and region 2 (HV2) sequences of the mtDNA control region was established from 162 unrelated Japanese individuals. The random match probability and the genetic diversity for this database were 0.96% and 0.997, respectively. Length heteroplasmy in the C-stretch regions located around position 16189 in HVI and 310 in HV2 was observed in 37% and 38% of the samples, respectively. A strategy using internal sequencing primers was devised to obtain confirmed sequences in these length heteroplasmic individuals. This database, combined with other mtDNA sequence databases from the Japanese population, will permit the significance of mtDNA match results to be properly reported in mtDNA typing casework in Japan.
从162名无亲缘关系的日本人中建立了线粒体DNA（mtDNA）控制区高变区1（HV1）和高变区2（HV2）序列的数据库。该数据库的随机匹配概率和遗传多样性分别为0.96%和0.997。在HV1中位于16189位置附近的C-延伸区和HV2中位于310位置附近的C-延伸区，分别在37%和38%的样本中观察到长度异质性。设计了一种使用内部测序引物的策略，以在这些长度异质性个体中获得确认的序列。该数据库与来自日本人群的其他mtDNA序列数据库相结合，将有助于在日本的mtDNA分型案件工作中正确报告mtDNA匹配结果的意义。
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