一些三唑基安替比林衍生物的合成及镇痛活性研究
Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity.
作者信息
Turan-Zitouni G, Sivaci M, Kiliç F S, Erol K
机构信息
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 26470, Eskişehir, Turkey.
出版信息
Eur J Med Chem. 2001 Jul-Aug;36(7-8):685-9. doi: 10.1016/s0223-5234(01)01252-1.
Abstract
The synthesis of some triazolyl-antipyrine derivatives starting from 4-chloroacetamidoantipyrine and 3-(aryloxyalkyl)-4-ethyl/phenyl-5-mercapto-1,2,4-triazoles is described. The chemical structures of the compounds were elucidated by IR, 1H-NMR and mass spectral studies. These compounds were tested for analgesic activity.
摘要
描述了从4-氯乙酰氨基安替比林和3-(芳氧基烷基)-4-乙基/苯基-5-巯基-1,2,4-三唑出发合成一些三唑基-安替比林衍生物的方法。通过红外光谱、1H-核磁共振光谱和质谱研究阐明了这些化合物的化学结构。对这些化合物进行了镇痛活性测试。
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