Dukelow S P, DeSouza J F, Culham J C, van den Berg A V, Menon R S, Vilis T
Graduate Program in Neuroscience, Siebens-Drake Research Institute, University of Western Ontario, London, Ontario N6G 2V4, Canada.
J Neurophysiol. 2001 Oct;86(4):1991-2000. doi: 10.1152/jn.2001.86.4.1991.
In humans, functional imaging studies have demonstrated a homologue of the macaque motion complex, MT+ [suggested to contain both middle temporal (MT) and medial superior temporal (MST)], in the ascending limb of the inferior temporal sulcus. In the macaque monkey, motion-sensitive areas MT and MST are adjacent in the superior temporal sulcus. Electrophysiological research has demonstrated that while MT receptive fields primarily encode the contralateral visual field, MST dorsal (MSTd) receptive fields extend well into the ipsilateral visual field. Additionally, macaque MST has been shown to receive extraretinal smooth-pursuit eye-movement signals, whereas MT does not. We used functional magnetic resonance imaging (fMRI) and the neural properties that had been observed in monkeys to distinguish putative human areas MT from MST. Optic flow stimuli placed in the full field, or contralateral field only, produced a large cluster of functional activation in our subjects consistent with previous reports of human area MT+. Ipsilateral optic flow stimuli limited to the peripheral retina produced activation only in an anterior subsection of the MT+ complex, likely corresponding to putative MSTd. During visual pursuit of a single target, a large portion of the MT+ complex was activated. However, during nonvisual pursuit, only the anterolateral portion of the MT+ complex was activated. This subsection of the MT+ cluster could correspond to putative MSTl (lateral). In summary, we observed three distinct subregions of the human MT+ complex that were arranged in a manner similar to that seen in the monkey.
在人类中，功能成像研究已在颞下沟的升支中证实了猕猴运动复合体MT+（推测包含中颞叶（MT）和颞上内侧叶（MST））的同源物。在猕猴中，运动敏感区域MT和MST在颞上沟中相邻。电生理研究表明，虽然MT感受野主要编码对侧视野，但MST背侧（MSTd）感受野延伸至同侧视野。此外，已表明猕猴的MST接收视网膜外的平稳跟踪眼动信号，而MT则不接收。我们使用功能磁共振成像（fMRI）以及在猴子身上观察到的神经特性来区分人类假定的MT区域和MST区域。全视野或仅对侧视野中的光流刺激在我们的受试者中产生了一大簇功能激活，这与先前关于人类MT+区域的报道一致。仅限于周边视网膜的同侧光流刺激仅在MT+复合体的前部子区域产生激活，可能对应于假定的MSTd。在对单个目标的视觉跟踪过程中，MT+复合体的大部分被激活。然而，在非视觉跟踪过程中，只有MT+复合体的前外侧部分被激活。MT+簇的这个子区域可能对应于假定的MSTl（外侧）。总之，我们观察到人类MT+复合体的三个不同子区域，其排列方式与在猴子中观察到的相似。
