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Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding.A激酶锚定蛋白（AKAP）与蛋白激酶A（PKA）调节亚基相互作用的分析：AKAP结合中的PKA亚型特异性
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Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels.小窝将蛋白激酶A信号传导定位于动脉ATP敏感性钾通道。
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Angiotensin II inhibition of ATP-sensitive K+ currents in rat arterial smooth muscle cells through protein kinase C.血管紧张素II通过蛋白激酶C抑制大鼠动脉平滑肌细胞中ATP敏感性钾电流。
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Dopaminergic modulation of voltage-gated Na+ current in rat hippocampal neurons requires anchoring of cAMP-dependent protein kinase.大鼠海马神经元中电压门控性Na+电流的多巴胺能调节需要环磷酸腺苷依赖性蛋白激酶的锚定。
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Delocalization of Endogenous A-kinase Antagonizes Rap1-Rho-α-Adrenoceptor Signaling in Human Microvascular Smooth Muscle Cells.内源性A激酶的去定位拮抗人微血管平滑肌细胞中的Rap1-Rho-α-肾上腺素能受体信号传导。
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本文引用的文献

1
Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1.将一种A激酶锚定蛋白AKAP79靶向内向整流钾通道Kir2.1。
J Biol Chem. 2001 Jun 8;276(23):20499-505. doi: 10.1074/jbc.M101425200. Epub 2001 Apr 3.
2
Angiotensin II inhibits rat arterial KATP channels by inhibiting steady-state protein kinase A activity and activating protein kinase Ce.血管紧张素II通过抑制稳态蛋白激酶A活性并激活蛋白激酶Ce来抑制大鼠动脉KATP通道。
J Physiol. 2001 Jan 15;530(Pt 2):193-205. doi: 10.1111/j.1469-7793.2001.0193l.x.
3
Role of K(ATP)(+) channels in regulation of systemic, pulmonary, and coronary vasomotor tone in exercising swine.K(ATP)(+)通道在运动猪的全身、肺和冠状动脉血管舒缩张力调节中的作用
Am J Physiol Heart Circ Physiol. 2001 Jan;280(1):H22-33. doi: 10.1152/ajpheart.2001.280.1.H22.
4
Calcium modulation of vascular smooth muscle ATP-sensitive K(+) channels: role of protein phosphatase-2B.血管平滑肌ATP敏感性钾通道的钙调节：蛋白磷酸酶2B的作用
Circ Res. 2000 Nov 24;87(11):1019-25. doi: 10.1161/01.res.87.11.1019.
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AKAP79 and the evolution of the AKAP model.A激酶锚定蛋白79与A激酶锚定蛋白模型的演变
FEBS Lett. 2000 Jun 30;476(1-2):58-61. doi: 10.1016/s0014-5793(00)01671-9.
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Sympathetic control of arterial membrane potential by ATP-sensitive K(+)-channels.ATP敏感性钾通道对动脉膜电位的交感神经控制。
Hypertension. 2000 Jan;35(1 Pt 2):379-84. doi: 10.1161/01.hyp.35.1.379.
7
Anchoring protein is required for cAMP-dependent stimulation of L-type Ca(2+) channels in rabbit portal vein.锚定蛋白是cAMP依赖性刺激兔门静脉L型钙通道所必需的。
Am J Physiol. 1999 Oct;277(4):C840-4. doi: 10.1152/ajpcell.1999.277.4.C840.
8
Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex.由相关磷酸酶-激酶信号复合体对N-甲基-D-天冬氨酸受体的调节。
Science. 1999 Jul 2;285(5424):93-6. doi: 10.1126/science.285.5424.93.
9
AKAPs: from structure to function.A激酶锚定蛋白：从结构到功能
Trends Cell Biol. 1999 Jun;9(6):216-21. doi: 10.1016/s0962-8924(99)01558-5.
10
ATP-sensitive K+ channel activation by calcitonin gene-related peptide and protein kinase A in pig coronary arterial smooth muscle.降钙素基因相关肽和蛋白激酶A对猪冠状动脉平滑肌中ATP敏感性钾通道的激活作用
J Physiol. 1998 Feb 15;507 ( Pt 1)(Pt 1):117-29. doi: 10.1111/j.1469-7793.1998.117bu.x.

A激酶锚定蛋白参与蛋白激酶A激活大鼠动脉K(ATP)通道的证据。

Evidence for involvement of A-kinase anchoring protein in activation of rat arterial K(ATP) channels by protein kinase A.

作者信息

Hayabuchi Y, Dart C, Standen N B

机构信息

Department of Cell Physiology and Pharmacology, University of Leicester, PO Box 138, Leicester LE1 9HN, UK.

出版信息

J Physiol. 2001 Oct 15;536(Pt 2):421-7. doi: 10.1111/j.1469-7793.2001.0421c.xd.

DOI:10.1111/j.1469-7793.2001.0421c.xd
PMID:11600677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2278879/
Abstract
  1. We have investigated the possible role of A-kinase anchoring proteins (AKAPs) in protein kinase A (PKA) signalling to ATP-sensitive K+ (K(ATP)) channels of rat isolated mesenteric arterial smooth muscle cells using whole-cell patch clamp and peptides that inhibit PKA-AKAP binding. 2. Intracellular Ht31 peptide (20 microM), which inhibits the PKA-AKAP interaction, blocked K(ATP) current activation by either dibutyryl cAMP or calcitonin gene-related peptide. Ht31-proline (20 microM), which does not inhibit PKA binding to AKAP, did not block K(ATP) current activation. 3. Ht31 reduced K(ATP) current activated by pinacidil and also prevented its inhibition by Rp-cAMPS, effects consistent with Ht31 blocking steady-state K(ATP) channel activation by PKA. However, Ht31 did not prevent K(ATP) current activation by the catalytic subunit of PKA. 4. An antibody to the RII subunit of PKA showed localization of PKA near to the cell membrane. Our results provide evidence that both steady-state and receptor-driven activation of K(ATP) channels by PKA involve the localization of PKA by an AKAP.
摘要
  1. 我们使用全细胞膜片钳技术以及抑制蛋白激酶A（PKA）与A激酶锚定蛋白（AKAPs）结合的肽段，研究了AKAPs在大鼠离体肠系膜动脉平滑肌细胞中PKA信号传导至ATP敏感性钾离子（K(ATP)）通道过程中可能发挥的作用。2. 抑制PKA-AKAP相互作用的细胞内Ht31肽（20微摩尔）可阻断二丁酰环磷腺苷（dibutyryl cAMP）或降钙素基因相关肽对K(ATP)电流的激活作用。不抑制PKA与AKAP结合的Ht31-脯氨酸（20微摩尔）则不会阻断K(ATP)电流的激活。3. Ht31可降低吡那地尔激活的K(ATP)电流，还可阻止其被Rp-环磷腺苷（Rp-cAMPS）抑制，这些效应与Ht31阻断PKA对K(ATP)通道的稳态激活作用一致。然而，Ht31并不能阻止PKA催化亚基对K(ATP)电流的激活。4. 一种针对PKA RII亚基的抗体显示PKA定位于细胞膜附近。我们的结果表明，PKA对K(ATP)通道的稳态激活和受体驱动激活均涉及AKAP对PKA的定位作用。