食管鳞状癌细胞系中缺乏人乳头瘤病毒16型和18型DNA。
Lack of human papillomavirus types 16 and 18 DNA in esophageal squamous carcinoma cell lines.
作者信息
Zheng J, Fu M, Wang X, Lin C, Wu M
机构信息
Department of Cell Biology, Cancer Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
出版信息
Chin Med J (Engl). 1999 Jun;112(6):534-7.
OBJECTIVE
To assess the role of human papillomavirus (HPV) in the carcinogenesis of the esophageal carcinomas in a high-incidence geographical area in Northern China.
METHODS
The presence of HPV types 16 and 18 DNA in the three esophageal carcinoma cell lines was examined by type-specific polymerase chain reaction (PCR).
RESULTS
No HPV type 16 and 18 DNA was found in any of the three esophageal carcinoma cell lines.
CONCLUSION
The results suggest that the role of HPV in human esophageal carcinogenesis in a high-incidence geographical area remains to be elucidated.
目的
评估人乳头瘤病毒（HPV）在中国北方食管癌高发地区食管癌发生过程中的作用。
方法
采用型特异性聚合酶链反应（PCR）检测三种食管癌细胞系中16型和18型HPV DNA的存在情况。
结果
在三种食管癌细胞系中均未发现16型和18型HPV DNA。
结论
结果表明，HPV在食管癌高发地区人类食管癌发生中的作用仍有待阐明。
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