Chiţu V, Diaconu C C, Veliceasa D, Ruţă S, Grancea C, Târdei G, Cernescu C E
HIV/AIDS Department, St. S. Nicolau Institute of Virology, Bucharest, Romania.
Rom J Virol. 1999 Jan-Dec;50(1-4):43-51.
Variability is a hallmark of HIV viruses both at the genetic and the phenotypic level. Viral sequencing and phylogenetic analysis of many isolates revealed specific distribution of HIV-1 subtypes according to the geographic location and route of transmission. In Romania, the currently available data coming from the study of pediatric HIV infection suggest the predominance of subtype F. However, there are few data concerning the distribution of HIV-1 subtypes among adults. We investigated the changes in the distribution of different HIV-1 subtypes among HIV-1 infected adult patients from Bucharest over a 6 years period (1992-1998) by means of V3 binding assays. The analysis of the relative incidence of different HIV-1 serotypes revealed the steady predominance of serotype F (50-75%) among the adults from Bucharest and a small but constant increase of the number of samples with serotype B- from 5% in 1994 to 14% in 1998. In contrast, the serotype E is either absent or weakly represented (4%) during the period of the study. All over the years there was a relatively high proportion (6-30%) of non-reactive samples. This could be an indication for the possible emergence of new or recombinant HIV-1 subtypes.
变异性是艾滋病毒在基因和表型水平上的一个特征。对许多分离株进行病毒测序和系统发育分析发现，HIV-1亚型根据地理位置和传播途径呈现出特定的分布。在罗马尼亚，目前来自儿科艾滋病毒感染研究的数据表明F亚型占主导地位。然而，关于HIV-1亚型在成人中的分布数据很少。我们通过V3结合试验调查了布加勒斯特1992年至1998年这6年间HIV-1感染成年患者中不同HIV-1亚型分布的变化。对不同HIV-1血清型相对发病率的分析显示，布加勒斯特成年人中F血清型持续占主导地位（50%-75%），B-血清型样本数量有小幅但持续的增加，从1994年的5%增至1998年的14%。相比之下，在研究期间E血清型要么不存在，要么占比很低（4%）。多年来，无反应样本的比例相对较高（6%-30%）。这可能表明可能出现了新的或重组的HIV-1亚型。
