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头孢噻吩和头孢匹林静脉注射后母体抗生素及其去乙酰化形式的血清水平和尿排泄情况。

Serum levels and urinary excretion of parent antibiotics and desacetyl forms after parenteral administration of cephalothin and cephapirin.

作者信息

Shimizu T

出版信息

Jpn J Antibiot. 1975 Aug;28(4):628-33.

PMID:1160152
Abstract

When the antibacterial substances of cephalothin and cephapirin in the serum and urine after intramuscular injection were separated and assayed, desacetyl metabolities of both drugs were detected. These tendencies were especially apparent in the tissue concentrations. When both the drugs were given intravenously to healthy volunteers, the amounts of their desacetyl metabolites were not greater in man than in rats.

摘要

对肌肉注射后血清和尿液中头孢噻吩和头孢匹林的抗菌物质进行分离和测定时，检测到了两种药物的去乙酰代谢物。这些趋势在组织浓度中尤为明显。当给健康志愿者静脉注射这两种药物时，其去乙酰代谢物的量在人体内并不比在大鼠体内多。

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Serum levels and urinary excretion of parent antibiotics and desacetyl forms after parenteral administration of cephalothin and cephapirin.头孢噻吩和头孢匹林静脉注射后母体抗生素及其去乙酰化形式的血清水平和尿排泄情况。
Jpn J Antibiot. 1975 Aug;28(4):628-33.
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引用本文的文献

1
Comparative pharmacokinetics and metabolism of cephapirin in laboratory animals and humans.头孢匹林在实验动物和人类中的比较药代动力学与代谢
Antimicrob Agents Chemother. 1976 Aug;10(2):307-17. doi: 10.1128/AAC.10.2.307.