Tan J S, Salstrom S J
Antimicrob Agents Chemother. 1979 Apr;15(4):510-2. doi: 10.1128/AAC.15.4.510.
The diffusibility of bacampicillin, ampicillin, cephalothin, and cephapirin into human interstitial fluid was investigated by using crossover studies. We compared bacampicillin with ampicillin and found that bacampicillin was better absorbed after oral administration. Blood, interstitial fluid, and urine levels were consistently higher in volunteers who received bacampicillin. We compared cephalothin with cephapirin and found that blood and interstitial fluid levels were comparable throughout the study.
通过交叉研究对巴卡西林、氨苄西林、头孢噻吩和头孢匹林在人组织间液中的扩散性进行了研究。我们将巴卡西林与氨苄西林进行比较，发现口服给药后巴卡西林吸收更好。接受巴卡西林的志愿者的血液、组织间液和尿液水平一直较高。我们将头孢噻吩与头孢匹林进行比较，发现在整个研究过程中血液和组织间液水平相当。
