30至58岁男性对慢性雄烯二醇-草药补充剂的内分泌和脂质反应。

Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30 to 58 year old men.

作者信息

Brown G A, Vukovich M D, Martini E R, Kohut M L, Franke W D, Jackson D A, King D S

机构信息

Department of Health and Hunan Performance, Iowa State University, Ames 50011, USA.

出版信息

J Am Coll Nutr. 2001 Oct;20(5):520-8. doi: 10.1080/07315724.2001.10719061.

DOI:10.1080/07315724.2001.10719061

PMID:11601567

Abstract

OBJECTIVE

The effectiveness of an androgenic nutritional supplement designed to enhance serum testosterone concentrations and prevent the formation of dihydrotestosterone and estrogen was investigated in healthy 3 to 58 year old men.

DESIGN

Subjects were randomly assigned to consume a nutritional supplement (AND-HB) containing 300-mg androstenediol, 480-mg saw palmetto, 450-mg indole-3-carbinol, 300-mg chrysin, 1,500 mg gamma-linolenic acid and 1.350-mg Tribulus terrestris per day (n = 28), or placebo (n = 27) for 28 days. Subjects were stratified into age groups to represent the fourth (30 year olds, n = 20), fifth (40 year olds, n = 20) and sixth (50 year olds, n = 16) decades of life.

MEASUREMENTS

Serum free testosterone, total testosterone, androstenedione, dihydrotestosterone, estradiol, prostate specific antigen and lipid concentrations were measured before supplementation and weekly for four weeks.

RESULTS

Basal serum total testosterone, estradiol, and prostate specific antigen (PSA) concentrations were not different between age groups. Basal serum free testosterone concentrations were higher (p < 0.05) in the 30- (70.5 +/- 3.6 pmol/L) than in the 50 year olds (50.8 +/- 4.5 pmol/L). Basal serum androstenedione and dihydrotestosterone (DHT) concentrations were significantly higher in the 30- (for androstenedione and DHT, respectively, 10.4 +/- 0.6 nmol/L and 2198.2 +/- 166.5 pmol/L) than in the 40- (6.8 +/- 0.5 nmol/L and 1736.8 +/- 152.0 pmol/L) or 50 year olds (6.0 +/- 0.7 nmol/L and 1983.7 +/- 147.8 pmol/L). Basal serum hormone concentrations did not differ between the treatment groups. Serum concentrations of total testosterone and PSA were unchanged by supplementation. Ingestion of AND-HB resulted in increased (p < 0.05) serum androstenedione (174%), free testosterone (37%), DHT (57%) and estradiol (86%) throughout the four weeks. There was no relationship between the increases in serum free testosterone, androstenedione, DHT, or estradiol and age (r2 = 0.08, 0.03, 0.05 and 0.02, respectively). Serum HDL-C concentrations were reduced (p < 0.05) by 0.14 mmol/L in AND-HB.

CONCLUSIONS

These data indicate that ingestion of androstenediol combined with herbal products does not prevent the formation of estradiol and dihydrotestosterone.

摘要

目的

在3至58岁的健康男性中，研究一种旨在提高血清睾酮浓度并防止二氢睾酮和雌激素形成的雄激素营养补充剂的有效性。

设计

受试者被随机分配，每天服用一种营养补充剂（AND-HB），其含有300毫克雄烯二醇、480毫克锯棕榈、450毫克吲哚-3-甲醇、300毫克白杨素、1500毫克γ-亚麻酸和1350毫克刺蒺藜（n = 28），或服用安慰剂（n = 27），为期28天。受试者被分层到不同年龄组，以代表生命中的第四个（30岁，n = 20）、第五个（40岁，n = 20）和第六个（50岁，n = 16）十年。

测量

在补充前及四周内每周测量血清游离睾酮、总睾酮、雄烯二酮、二氢睾酮、雌二醇、前列腺特异性抗原和脂质浓度。

结果

各年龄组之间的基础血清总睾酮、雌二醇和前列腺特异性抗原（PSA）浓度无差异。30岁组（70.5±3.6皮摩尔/升）的基础血清游离睾酮浓度高于50岁组（50.8±4.5皮摩尔/升）（p < 0.05）。30岁组的基础血清雄烯二酮和二氢睾酮（DHT）浓度显著高于40岁组（雄烯二酮和DHT分别为10.4±0.6纳摩尔/升和2198.2±166.5皮摩尔/升）和50岁组（6.0±0.7纳摩尔/升和1983.7±147.8皮摩尔/升）。治疗组之间的基础血清激素浓度无差异。补充后血清总睾酮和PSA浓度未改变。摄入AND-HB导致在四周内血清雄烯二酮（174%）、游离睾酮（37%）、DHT（57%）和雌二醇（86%）升高（p < 0.05）。血清游离睾酮、雄烯二酮、DHT或雌二醇的升高与年龄之间无相关性（r2分别为0.08、0.03、0.05和0.02）。AND-HB组的血清高密度脂蛋白胆固醇（HDL-C）浓度降低了0.14毫摩尔/升（p < 0.05）。