Department of Anti-Doping Research, Institute of Sport, Warsaw, Poland.
Department of Endocrinology, Institute of Sport, Warsaw, Poland.
J Hum Kinet. 2014 Jul 8;41:99-105. doi: 10.2478/hukin-2014-0037. eCollection 2014 Jun 28.
Herbal and nutritional supplements are more and more popular in the western population. One of them is an extract of an exotic plant, named Tribulus terrestris (TT). TT is a component of several supplements that are available over-the-counter and widely recommended, generally as enhancers of human vitality. TT is touted as a testosterone booster and remedy for impaired erectile function; therefore, it is targeted at physically active men, including male athletes. Based on the scientific literature describing the results of clinical trials, this review attempted to verify information on marketing TT with particular reference to the needs of athletes. It was found that there are few reliable data on the usefulness of TT in competitive sport. In humans, a TT extract used alone without additional components does not improve androgenic status or physical performance among athletes. The results of a few studies have showed that the combination of TT with other pharmacological components increases testosterone levels, but it was not discovered which components of the mixture contributed to that effect. TT contains several organic compounds including alkaloids and steroidal glycosides, of which pharmacological action in humans is not completely explained. One anti-doping study reported an incident with a TT supplement contaminated by a banned steroid. Toxicological studies regarding TT have been carried out on animals only, however, one accidental poisoning of a man was described. The Australian Institute of Sport does not recommend athletes' usage of TT. So far, the published data concerning TT do not provide strong evidence for either usefulness or safe usage in sport.
草药和营养补充剂在西方人群中越来越受欢迎。其中一种是一种外来植物的提取物,名为蒺藜(TT)。TT 是几种可在柜台上购买且广泛推荐的补充剂的成分,通常被用作增强人体活力的物质。TT 被吹捧为一种睾丸激素增强剂和改善勃起功能障碍的药物;因此,它针对的是积极运动的男性,包括男性运动员。基于描述临床试验结果的科学文献,本综述试图验证有关 TT 营销的信息,特别是针对运动员的需求。结果发现,关于 TT 在竞技体育中的有用性的可靠数据很少。在人类中,单独使用 TT 提取物而不添加其他成分并不能改善运动员的雄激素状态或身体表现。少数研究的结果表明,TT 与其他药理成分的组合会增加睾丸激素水平,但尚未发现混合物中的哪些成分对此有影响。TT 含有几种有机化合物,包括生物碱和甾体糖苷,其在人类中的药理作用尚未完全解释清楚。一项反兴奋剂研究报告了一起 TT 补充剂被禁用类固醇污染的事件。关于 TT 的毒理学研究仅在动物身上进行过,但曾有一例男子意外中毒的报告。澳大利亚体育学院不建议运动员使用 TT。到目前为止,有关 TT 的已发表数据既没有提供强有力的证据证明其在运动中的有用性,也没有提供其安全性的证据。