Hooper J W, Larsen T, Custer D M, Schmaljohn C S
Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA.
Virology. 2001 Oct 10;289(1):6-14. doi: 10.1006/viro.2001.1133.
Hantaviruses are associated with two human diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Development of vaccines and therapies to prevent and treat HFRS and HPS have been hampered by the absence of a practical animal model. Here we report that Andes virus (ANDV), a South American hantavirus, is highly lethal in adult Syrian hamsters. The characteristics of the disease in hamsters, including the incubation period, symptoms of rapidly progressing respiratory distress, and pathologic findings of pulmonary edema and pleural effusion, closely resemble HPS in humans. This is the first report of a lethal disease model for hantaviruses that causes HPS.
汉坦病毒与两种人类疾病相关，即肾综合征出血热（HFRS）和汉坦病毒肺综合征（HPS）。由于缺乏实用的动物模型，预防和治疗HFRS和HPS的疫苗及疗法的研发受到了阻碍。在此我们报告，南美汉坦病毒安第斯病毒（ANDV）对成年叙利亚仓鼠具有高度致死性。仓鼠所患疾病的特征，包括潜伏期、迅速进展的呼吸窘迫症状以及肺水肿和胸腔积液的病理表现，与人类的HPS极为相似。这是关于导致HPS的汉坦病毒致死性疾病模型的首次报告。
