Kamitakahara M, Kawashita M, Kokubo T, Nakamura T
Department of Material Chemistry, Graduate School at Engineering, Kyoto University, Yoshida, Japan.
Biomaterials. 2001 Dec;22(23):3191-6. doi: 10.1016/s0142-9612(01)00071-0.
Glass-ionomer cements, which consist of CaO-Al2O3-SiO2-CaF2 glass powders and a polyalkenoic acid solution, such as polyacrylic acid (PAA), have been widely used in dentistry. They set rapidly without any shrinkage, the lack of temperature increase on reaction, and develop high mechanical strength. Therefore, if bioactive glass-ionomer cements can be obtained, such cements are expected to be useful as cements for fixing orthopaedic implants to the surrounding bone. In the present study, to examine the possibility of obtaining bioactive glass-ionomer cements, the effect of PAA on the apatite formation on bioactive ceramics in a simulated body fluid was investigated. It was revealed that presence of even a small quantity of PAA inhibits the apatite formation in the body environment. It is speculated that when glass-ionomer cements are implanted into the body, PAA can be released from the glass-ionomer cements and inhibits the apatite formation on their surfaces. It is reasonable to suppose that this will occur with any glass-ionomer cement that contains PAA. Therefore, it might be considered difficult to obtain bioactive glass-ionomer cements.
玻璃离子水门汀由CaO - Al2O3 - SiO2 - CaF2玻璃粉和聚烯酸溶液（如聚丙烯酸（PAA））组成，已在牙科领域广泛应用。它们凝固迅速且无任何收缩，反应时无温度升高，并能形成较高的机械强度。因此，如果能获得生物活性玻璃离子水门汀，这类水门汀有望用作将骨科植入物固定到周围骨骼的水门汀。在本研究中，为了探究获得生物活性玻璃离子水门汀的可能性，研究了PAA对模拟体液中生物活性陶瓷上磷灰石形成的影响。结果表明，即使存在少量PAA也会抑制体内环境中磷灰石的形成。据推测，当玻璃离子水门汀植入体内时，PAA会从玻璃离子水门汀中释放出来并抑制其表面磷灰石的形成。可以合理推测，任何含PAA的玻璃离子水门汀都会出现这种情况。因此，可能很难获得生物活性玻璃离子水门汀。
