Nicholson John W, Sidhu Sharanbir K, Czarnecka Beata
Bluefield Centre for Biomaterials, 152-160 City Road, London EC1V 2NX, UK and Dental Physical Sciences, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Centre for Oral Bioengineering, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, UK.
Heliyon. 2024 Feb 2;10(3):e25239. doi: 10.1016/j.heliyon.2024.e25239. eCollection 2024 Feb 15.
This paper reviews the chemical behaviour of glass polyalkenoate (glass-ionomer) dental cements, both conventional and resin-modified, in contact with natural tissues, with the aim of determining whether these materials can be considered to be bioactive.
Relevant papers describing the behaviour of bioactive glasses and ceramics, and glass-ionomer (glass polyalkenoate) cements have been identified using PubMed and Science Direct. This has allowed a comparison to be made between the behaviour of glass-ionomers and the speciality glasses and ceramics that are widely classified as bioactive, a designation considered valid for over fifty years. More recent papers concerning bioactive metals and polymers have also been studied and both and studies are included.
Have included general papers on the chemistry and biological behaviour of bioactive glasses and ceramics, as well as papers on glass-ionomers dealing with (i) ion release, (ii) bonding to the surface of teeth, (iii) influence on surrounding pH and (iv) interaction with bone.
The literature shows that glass-ionomers (glass polyalkenoates) have three types of behaviour that are similar to those of bioactive glasses as follows: Formation of direct bonds to living tissue (teeth and bones) without fibrous capsule; release of biologically beneficial ions; and change of the local pH. However, in tests, they do not cause calcium phosphate to precipitate from solutions of simulated body fluid, SBF. Despite this, studies show that, in patients, glass-ionomers interact chemically with hard tissues and this suggests that may indeed be considered bioactive.
本文综述了传统型和树脂改性型玻璃聚烯酸酯（玻璃离子）牙科水门汀与天然组织接触时的化学行为，旨在确定这些材料是否可被视为具有生物活性。
使用PubMed和ScienceDirect检索了描述生物活性玻璃和陶瓷以及玻璃离子（玻璃聚烯酸酯）水门汀行为的相关论文。这使得能够对玻璃离子水门汀与被广泛归类为生物活性材料的特种玻璃和陶瓷的行为进行比较，这种归类已被认可五十多年。还研究了有关生物活性金属和聚合物的最新论文，并纳入了体内和体外研究。
包括关于生物活性玻璃和陶瓷的化学及生物学行为的综述论文，以及关于玻璃离子水门汀的论文，内容涉及（i）离子释放、（ii）与牙齿表面的粘结、（iii）对周围pH值的影响以及（iv）与骨的相互作用。
文献表明，玻璃离子水门汀（玻璃聚烯酸酯）具有三种与生物活性玻璃类似的行为：与活组织（牙齿和骨骼）形成直接结合而无纤维包膜；释放对生物有益的离子；以及改变局部pH值。然而，在体外试验中，它们不会使磷酸钙从模拟体液（SBF）溶液中沉淀出来。尽管如此，研究表明，在患者体内，玻璃离子水门汀与硬组织发生化学相互作用，这表明它们确实可被视为具有生物活性。
