Szabó G, Magyar Z, Jakab F
Lymphology. 1975 Jun;8(2):29-36.
Na125I and 131I-labeled albumin was infused in dogs into the common bile duct at pressures of 20 to 25 and 40 mmHg. At 40 mmHg, the amounts of the iodide ion and labeled albumin in circulating plasma were, after correction for the secondary loss from the circulation, nearly identical. At 20-25 mmHg more iodid than labeled albumin was found in the circulation. In thoracic duct lymph the same fraction of the infused amount of albumin was recovered at both pressures. Lymphatic concentrations of albumin were in both types of experiments substantially higher than plasma concentrations. It is concluded, that at increased pressure fluid leaks first from the small biliary ducts into the Mall's spaces. In consequence of water absorption and the diffusion of ions and small molecules into the blood capillaries the concentrations of protein or protein bound molecules in this part of the hepatic interstitial fluid increases. This is reflected in their high concentration in the lymph. If bile pressure rises further, fluid leaks also into the Disse's spaces. This leads to a bulk flow of solvent and solutes into the sinusoids and to the near disappearance of the differences in the venous transport of ions and colloids.
将碘化钠（Na125I）和碘化钠（131I）标记的白蛋白以20至25 mmHg和40 mmHg的压力注入狗的胆总管。在40 mmHg时，经循环中二次损失校正后，循环血浆中碘离子和标记白蛋白的量几乎相同。在20 - 25 mmHg时，循环中发现的碘化物比标记白蛋白多。在胸导管淋巴液中，两种压力下回收的白蛋白注入量的比例相同。两种类型的实验中，淋巴液中白蛋白的浓度均显著高于血浆浓度。得出的结论是，压力升高时，液体首先从小胆管漏入Mall间隙。由于水的吸收以及离子和小分子扩散到毛细血管中，肝间质液中这部分蛋白质或蛋白质结合分子的浓度增加。这反映在它们在淋巴液中的高浓度上。如果胆汁压力进一步升高，液体也会漏入Disse间隙。这会导致溶剂和溶质大量流入肝血窦，并使离子和胶体的静脉转运差异几乎消失。
