Acharya A, Sanyal S K, Moulik S P
Department of Chemistry, Centre for Surface Science, Jadavpur University, 700 032, Calcutta, India.
Int J Pharm. 2001 Oct 23;229(1-2):213-26. doi: 10.1016/s0378-5173(01)00863-8.
The microemulsification of eucalyptol/polyoxyethylene(4)lauryl ether (Brij-30)/ethanol/water has been investigated. The phase behaviours of the mixed system in pseudoternary and tetrahedral representations have been examined to understand the topological nature of the multicomponent mixtures. Phase volumes of the heterogeneous combinations have been estimated to understand the mixing efficacy of the combinations. Shear viscosities of different monophasic compositions have been measured at different shear rates and temperatures, and the activation parameters for the viscous flow have been evaluated. The dimensions of the nanodispersions of w/o and o/w types, their diffusion coefficients and the polydispersity have been determined by the DLS method. The energetics of solubilisation (dissolution) of water in oil+Brij-30+ethanol as well as oil in water+Brij-30+ethanol forming w/o and o/w microemulsions, respectively, have been calorimetrically determined. Considering the phase separation point to be the point of maximum solubility, the energetic parameters (enthalpy, free energy and entropy) of the microemulsification process have been estimated.
对桉叶油素/聚氧乙烯(4)月桂醚（Brij-30）/乙醇/水的微乳化过程进行了研究。考察了该混合体系在拟三元和四面体表示中的相行为，以了解多组分混合物的拓扑性质。估算了非均相组合的相体积，以了解各组合的混合效果。在不同剪切速率和温度下测量了不同单相组合物的剪切粘度，并评估了粘性流动的活化参数。通过动态光散射（DLS）方法测定了水包油型和油包水型纳米分散体的尺寸、扩散系数和多分散性。分别通过量热法测定了水在油+Brij-30+乙醇以及油在水+Brij-30+乙醇中形成水包油型和油包水型微乳液时的增溶（溶解）能量学。将相分离点视为最大溶解度点，估算了微乳化过程的能量参数（焓、自由能和熵）。
