Anasetti C, Petersdorf E W, Martin P J, Woolfrey A, Hansen J A
Department of Medicine, Division of Oncology, University of Washington, Seattle, Washington, USA.
Curr Opin Hematol. 2001 Nov;8(6):337-41. doi: 10.1097/00062752-200111000-00004.
Transplants of hematopoietic stem cells from unrelated donors have become feasible for patients with a growing variety of hematologic disorders. The probability of finding a suitable donor has increased because of the expansion of the network of registries containing more than seven million HLA-typed donors worldwide. The selection of compatible donors has become more effective, thanks to the discovery of new HLA alleles and the development of precise and efficient HLA typing methods using DNA technology. Improved methods for transplantation may provide the opportunity to further decrease treatment-related toxicity and improve survival.
对于患有越来越多血液系统疾病的患者来说，来自无关供体的造血干细胞移植已变得可行。由于全球范围内包含超过700万HLA分型供体的登记网络不断扩大，找到合适供体的可能性增加了。由于发现了新的HLA等位基因以及使用DNA技术开发了精确高效的HLA分型方法，兼容供体的选择变得更加有效。改进的移植方法可能会提供进一步降低治疗相关毒性并提高生存率的机会。
