Hurley C K, Fernandez Vina M, Setterholm M
Department of Oncology, CW Bill Young Marrow Donor Recruitment and Research Program, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA.
Tissue Antigens. 2003 Jun;61(6):415-24. doi: 10.1034/j.1399-0039.2003.00096.x.
Today, more than 50 registries of HLA-typed potential adult hematopoietic stem cell donors have been established in 40 countries and include more than 7.5 million volunteers. HLA testing of new volunteers includes HLA-A, -B and often -DR typing at low to intermediate resolution. Searching patients are tested for these same loci, preferably at a higher level of resolution. Over 95,000 patient searches are received by registries annually resulting in approximately 4660 unrelated transplants. In 2001, nearly one-third of transplants involved a patient in one country receiving stem cells from a donor in another. The diversity of the HLA system complicates the search process, requiring sophisticated registry algorithms for matching, and expertise in allele and haplotype frequencies and associations to design search strategies. Within registries, HLA frequency data have been used to evaluate optimal registry size and composition.
如今，40个国家已建立了50多个登记有人类白细胞抗原（HLA）分型的潜在成年造血干细胞供者信息库，志愿者超过750万。新志愿者的HLA检测包括低至中等分辨率的HLA-A、-B分型，通常还包括-DR分型。待检索患者也会针对这些相同位点进行检测，最好是更高分辨率的检测。登记处每年收到超过95000次患者检索请求，促成约4660例非亲缘移植。2001年，近三分之一的移植涉及一个国家的患者接受来自另一个国家供者的干细胞。HLA系统的多样性使检索过程变得复杂，需要复杂的登记算法进行匹配，以及等位基因和单倍型频率及关联方面的专业知识来设计检索策略。在各登记处内部，HLA频率数据已被用于评估最佳登记库规模和构成。
