Borovanský J, Duchon J
Neoplasma. 1975;22(2):195-9.
The amino acid composition of melanosomes from human and Harding-Passey mouse melanomas and from pigmented tissues of cattle eyes isolated according to BOLT was studied. The 18 current amino acids and moreover dopa were found in all the hydrolysates studied. By means of apolar/polar amino acid ratio suggested by HATCH the possible properties of melanosomal protein(s) were infered. The higher level of cysteine and lysine in mouse melanosomes as compared with tyrosinase supports the theory of special matrix protein in melanosomes. Lysine seems to have a role in regulation of the quantity of synthesized melanin.
对根据博尔特方法分离出的人类和哈丁 - 帕西小鼠黑色素瘤以及牛眼色素组织中的黑素小体的氨基酸组成进行了研究。在所研究的所有水解产物中都发现了18种常见氨基酸以及多巴。借助哈奇提出的非极性/极性氨基酸比例，推断了黑素小体蛋白质的可能特性。与酪氨酸酶相比，小鼠黑素小体中半胱氨酸和赖氨酸水平较高，这支持了黑素小体中存在特殊基质蛋白的理论。赖氨酸似乎在合成黑色素的数量调节中起作用。
