多巴和5-S-半胱氨酰多巴在哈丁-帕西黑色素瘤中的细胞内分布。
Intracellular distribution of dopa and 5-S-cysteinyldopa in Harding-Passey melanoma.
作者信息
Agrup G, Falck B, Rorsman H, Rosengren A M, Rosengren E
出版信息
Acta Derm Venereol. 1977;57(4):313-5.
The concentrations of dopa and 5-S-cysteinyldopa were determined in the various cell fractions of Harding-Passey melanomas. Dopa was present in larger amounts than was 5-S-cysteinyldopa in all cell fractions, but the dopa/5-S-cysteinyldopa ratio was lower in the soluble fraction and in the small-granule fraction than in the large-granule fraction. The soluble fraction contained the greatest amount of catechols. These findings are compatible with high tyrosinase activity not only in the melanosomes but also in the small-granule and soluble fractions.
在哈丁-帕西黑色素瘤的各种细胞组分中测定了多巴和5-S-半胱氨酰多巴的浓度。在所有细胞组分中，多巴的含量均高于5-S-半胱氨酰多巴，但可溶组分和小颗粒组分中的多巴/5-S-半胱氨酰多巴比值低于大颗粒组分。可溶组分中儿茶酚的含量最高。这些发现不仅与黑素小体中，而且与小颗粒和可溶组分中的高酪氨酸酶活性相符。
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