Borovanský J
Neoplasma. 1978;25(3):349-52.
Melanin concentration which represents one of biochemical parameters expressing the degree of pigment cell differentiation was studied by new gravimetric procedure in human, Bomirski hamster, Harding-Passey mouse and horse melanomas and also in several non-tumor pigment tissues. In amelanotic varieties of human and hamster melanomas relatively high melanin level was discovered. This finding (together with known electron microscopic evidence of pre-melanosomes presence in some amelanotic melanomas) suggests that the term "amelanotic" is not correct. Comparison of melanin content between melanomas and normal pigment tissues clearly demonstrates in quantitative way that as for melanomas their proliferation does not decrease the degree of their biochemical differentiation.
黑色素浓度作为表示色素细胞分化程度的生化参数之一，采用新的重量法在人类、博米尔斯基仓鼠、哈丁 - 帕西小鼠和马的黑色素瘤以及几种非肿瘤色素组织中进行了研究。在人类和仓鼠黑色素瘤的无黑色素变种中发现了相对较高的黑色素水平。这一发现（连同一些无黑色素黑色素瘤中存在前黑素小体的已知电子显微镜证据）表明“无黑色素的”这一术语并不准确。黑色素瘤与正常色素组织之间黑色素含量的比较以定量方式清楚地表明，就黑色素瘤而言，它们的增殖并未降低其生化分化程度。
