Isermann G T, Kaminski E J
Oral Surg Oral Med Oral Pathol. 1979 Oct;48(4):353-7. doi: 10.1016/0030-4220(79)90036-7.
Twenty-six teeth from 8-month-old beagle dogs were used to evaluate the pulpal response to bacteria in bacterially contaminated minimally exposed and unexposed pulp in the dog. The effects were evaluated by means of serial radiographs, consecutive vital dye injections, and histologic sections. Periapical lesions developed in all of the eight teeth which were bacterially infected and exposed. Out of ten teeth which were bacterially infected and had cavities without pulp exposure, only two teeth in the acute group demonstrated inflammatory changes and loss of odontoblastic function directly beneath the infected dentinal tubules. Within the limits of the experimental design, this study demonstrated the pulpal responses of the dog with respect to bacteria.
使用8个月大比格犬的26颗牙齿来评估犬牙髓对细菌污染的轻度暴露和未暴露牙髓中细菌的反应。通过系列X线片、连续的活体染料注射和组织学切片来评估效果。所有8颗受到细菌感染且暴露的牙齿均出现根尖周病变。在10颗受到细菌感染且有龋洞但牙髓未暴露的牙齿中，急性组只有两颗牙齿在感染的牙本质小管下方出现炎症变化和成牙本质细胞功能丧失。在实验设计的范围内，本研究证明了犬牙髓对细菌的反应。
