Hughes R N, Greig A M
Psychopharmacologia. 1975 Jun 19;42(3):289-92. doi: 10.1007/BF00421270.
Reactions to novelty, rearing and ambulation were observed in rats following saline or chlordiazepoxide injections either with or without prior drug experience. Drug suppression of the former two response was evident but there was no indication of prior drug experience being effective. However, experience appeared to negate the compound's depressant effect on ambulation shown by inexperienced subjects. It was concluded that inhibitory influences of chlordiazepoxide on reactions to novelty and rearing can not be ascribed to the aversive effects of a novel drug state.
在有或没有先前用药经历的大鼠中，观察了注射生理盐水或氯氮䓬后对新奇事物、竖毛和活动的反应。该化合物对前两种反应的抑制作用明显，但没有迹象表明先前的用药经历会产生影响。然而，经验似乎抵消了该化合物对无经验受试者活动的抑制作用。得出的结论是，氯氮䓬对新奇事物和竖毛反应的抑制作用不能归因于新药物状态的厌恶效应。
